BRL 26830A and weight loss

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Weight loss in obese subjects on a restricted diet given BRL 26830A, a new atypical beta adrenoceptor agonist.

A double blind placebo controlled study was carried out in 40 subjects newly referred for treatment for obesity to determine the effects of the new thermogenic beta adrenoceptor agonist BRL 26830A. The subjects were randomised to receive either BRL 26830A, 200 mg daily for two weeks then 400 mg daily, or placebo for 18 weeks, and all were instructed to follow a 3.35 MJ diet that was low in fat ...

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BACKGROUND Diet-induced weight loss is accompanied by adaptive thermogenesis, ie, a disproportional or greater than expected reduction of resting metabolic rate (RMR). OBJECTIVE The aim of this study was to investigate whether adaptive thermogenesis is sustained during weight maintenance after weight loss. DESIGN Subjects were 22 men and 69 women [mean ± SD age: 40 ± 9 y; body mass index (B...

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ژورنال

عنوان ژورنال: BMJ

سال: 1988

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.296.6638.1737-a